In the Columbia Center for Human Development (CCHD), we want to understand the molecular mechanisms underlying cellular plasticity in various cultured stem cells and developmental stages as well as in regeneration and cancer. We employ both genomic and proteomic approaches combined with cellular and animal models to dissect the regulatory layers encompassing transcriptional, post-transcriptional, translational and post-translational mechanisms that control cellular plasticity.
Previous and ongoing research projects encompass the following five areas:
