In the Columbia Center for Human Development (CCHD), the Columbia Stem Cell Initiative (CSCI), and Herbert Irving Comprehensive Cancer Center (HICCC), we want to understand the molecular mechanisms underlying the stemness of totipotent, pluripotent, and cancer cells in development and disease. We employ both genomic and proteomic approaches combined with cellular and mouse models to dissect the regulatory layers encompassing transcriptional, post-transcriptional, translational, and post-translational mechanisms that control cell fate determination and reprogramming.
Previous and ongoing research projects encompass the following five areas:
