2022
Malik, V., Zang, R., Fuentes-Iglesias, A., Huang, X., Li, D., Fidalgo, M., Zhou, H., and Wang, J. (2022). Comparative functional genomics identifies unique molecular features of EPSCs. Life Science Alliance, In Press.
Nobre, A.R., Dalla, E., Yang, J., Huang, X., Wullkopf, L., Risson, E., Razghandi, P., Anton, M.L., Zheng, W., Seoane, J.A., Curtis, C., Kenigsberg, E., Wang, J., and Aguirre-Ghiso, J.A. (2022). Single-cell analysis of early disseminated cancer cells identifies ZFP281 and a mesenchymal-like dormancy program as a barrier to metastasis. Nature Cancer, In Press.
Yang, J.-M.*, Ren, Y., Kumar, A., Xiong, X., Das, J.K., Peng, H.-Y., Wang, L., Ren, X., Zhang, Y., Ji, C., Cheng, Y., Zhang, L., Alaniz, R.C., de Figueiredo, P., Fang, D., Zhou, H., Liu, X., Wang, J.*, and Song, J.*  (2022). NAC1 modulates autoimmunity by suppressing regulatory T cell-mediated tolerance. Science Advances Jul;8(26):eabo0183. doi: 10.1126/sciadv.abo0183. Epub 2022 Jun 29. (*Corresponding authors). PMID: 35767626.
Huang, X., Bashkenova, N., Hong, Y., Guallar, D., Hu, Z., Malik, V., Li, D., Shen, X., Zhou, H., and Wang, J. (2022). A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency. Cell Reports 39 (10), 110928. PMID: 35675764.​
Malik, V., and Wang, J. (2022). Pursuing totipotency: authentic totipotent stem cells in culture. Trends in Genetics 38 (7), 632-636. PMID: 35443932.
Li, D., Yang, J., Huang, X., Zhou, H., and Wang, J. (2022). eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency. Science Advances 8 (13), online version PMID: 35353581.
 https://www.science.org/doi/10.1126/sciadv.abm0478​
Shao, W., Bi, X., Pan, Y., Gao, B., Wu, J., Yin, Y., Liu, Z., Peng, M., Zhang, W., Jiang, X., Ren, W., Xu, Y., Wu, Z., Wang, K., Zhan, G., Lu, J.Y., Han, X., Li, T., Wang, J., Li, G., Deng, H., Li, B., and Shen, X. (2022). Phase separation of RNA-binding protein promotes polymerase binding and transcription. Nature Chemical Biology  18 (1), 70-80. PMID: 34916619.
Zang, R., Huang, X., Li, D., Zhou, H., Gao, S., and Wang, J. (2022). Zfp281 is essential for epiblast maturation through a cell-autonomous effect. Journal of Genetics and Genomics 49, 85-88. PMID: 34543730.
2021
Huang, X., Park, K., Gontarz, P., Zhang, B., Pan, J., McKenzie, Z., Fischer, L.A., Dong, C., Dietmann, S., Xing, X., Shliaha, P.V., Yang, J., Li, D., Ding, J., Lungjangwa, T., Mitalipova, M., Khan, S.A., Imsoonthornruksa, S., Jensen, N., Wang, T., Kadoch, C., Jaenisch, R., Wang, J.*, and Theunissen, T.W.* (2021). Oct4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human. Nature Communications 12:5123. (*Corresponding authors) PMID: 34446700.
Sun, Z., Yu, H., Zhao, J., Tan, T., Pan, H., Zhu, Y., Chen, L., Zhang, C., Zhang, L., Lei, A., Xu, Y., Bi, X., Huang, X., Gao, B., Wang, L., Correia, C., Chen, M., Sun, Q., Feng, Y., Shen, L., Wu, H., Wang, J., Shen, X., Daley, G. Q., Li, H., and Zhang, J. (2021). LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell 13(7):490-512. PMID: 34331666.
Wang, J., Yu, H., Ma, Q., Zeng, P., Wu, D., Hou, Y., Liu, X., Jia, L., Sun, J., Chen, Y., Guallar, D., Fidalgo, M., Chen, J., Yu, Y., Jiang, S., Li, F., Zhao, C., Huang, X., Wang, J., Li, C., Sun, Y., Zeng, X., Zhang, W., Miao, Y., and Ding, J. (2021). Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions. Cell Stem Cell 28(10):1868-1883. PMID: 34038708.
Huang X., Bashkenova, N., Yang, J., Li, D., and Wang, J. (2021). Zfp281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency. Protein & Cell 12(3), 213-219. PMID: 32812113.
2020
Lan, J., Rajan, N., Bizet, M., Penning, A., Singh, N.K., Guallar, D., Calonne, E., Greci, A.L., Bonvin, E., Deplus, R., Hsu, P.J., Nachtergaele, S., Ma, C., Song, R., Fuentes-Iglesias, A., Hassabi, B., Putmans, P., Mies, F., Menschaert, G., Wong, J.J.L., Wang, J., Fidalgo, M., Yuan, B., and Fuks, F. (2020). ​Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nature Communications 11(1):4956. doi: 10.1038/s41467-020-18729-6. PMID: 33009383.
Fuentes-Iglesias, A., Garcia-Outeiral, V., Pardavila, J. A., Wang, J.*, Fidalgo, M.,* and Guallar, D.* (2020). An optimized immunoprecipitation protocol for assessing protein-RNA interactions in vitro. STAR Protocols 1(2):100093. doi: 10.1016/j.xpro.2020.100093. Epub 2020 Aug 26. PMID: 32995755 (*Corresponding authors)
Salik, B., Yi, H., Hassan, N., Santiappillai, N., Vick, B., Connerty, P., Duly, A., Trahair, T., Woo, A.J., Beck, D., Liu, T., Spiekermann, K., Jeremias, I., Wang, J., Kavallaris, M., Haber, M., Norris, M.D., Liebermann, D.A., D'Andrea, R.J., Murriel, C., Wang, J.Y. (2020). Targeting RSPO3-LGR4 signaling for leukemia stem cell eradication in acute myeloid leukemia. Cancer Cell 38, 263-278. PMID: 32559496.
Guallar, D.*, Fuentes-Iglesias, A., Souto, Y., Ameneiro, C., Freire-Agulleiro, O., Pardavila, J.A., Escudero, A., Garcia-Outeiral, V., Moreira, T., Saenz, C., Xiong, H., Liu, D., Xiao, S., Hou, Y., Wu, K., Torrecilla, D., Hartner, J.C., Blanco, M.G., Lee, L.J., Lopez, M., Walkley, C.R., Wang, J.*#, and Fidalgo, M.* (2020). ADAR1-dependent RNA editing promotes MET and iPSC reprogramming by alleviating ER stress. Cell Stem Cell 27(2), 300-314. PMID:32396862. (*Corresponding authors; #Lead Contact)
Li, D., and Wang, J. (2020). ​Ribosome heterogeneity in stem cells and development. Journal of Cell Biology 1;219(6). pii: e202001108. doi: 10.1083/jcb.202001108. PMID:32330234
Li, D., Kishta, M.S., and Wang J. (2020). Regulation of pluripotency and reprogramming by RNA binding proteins. Curr. Topics Dev. Biol. 138, 113-138. ​PMID:32220295
DOI: 10.1016/bs.ctdb.2020.01.003. 
Yang, F., Huang, X., Zang, R., Chen, J., Fidalgo, M., Sanchez-Priego, C., Yang, J., Caichen, A., Ma, F., Macfarlan, T., Wang, H., Gao, S., Zhou, H., and Wang, J. (2020). DUX-miR-344-ZMYM2-mediated activation of MERVL LTRs induces a totipotent 2C-like state. Cell Stem Cell 26, 234-250. ​ PMID:32032525
Yang, J., Bashkenova, N., Zang, R., Huang, X., and Wang, J. (2020). The roles of TET family proteins in development and stem cells. Development 147(2): dev183129 doi: 10.1242/dev.183129 
Published 15 January 2020. PMID:31941705.
Zhang, H., Wu, Z., Lu, J.Y., Huang, B., Zhou, H., Xie, W., Wang, J., and Shen, X. (2020). DEAD-box helicase 18 counteracts PRC2 to safeguard ribosomal DNA in pluripotency regulation. Cell Reports 30, 81-97. PMID:31914400.
2019
Woo, A.J., Patry, C., Ghamari, A., Pregernig, G., Zheng, K., Piers, T., Hibbs, M., Li, J.K., Fidalgo, M., Wang, J., Lee, J.-H., Leedman, P.J., Wang, J., Fraenkel, E., and Cantor, A.B. (2019). Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood Adv. 3(16):2499-2511. doi: 10.1182/bloodadvances.2018030551. PMID:31455666
Gonzales-Aloy, E., Connerty, P., Salik, B., Liu, B., Woo, A. J., Haber, M., Norris, M.D., Wang, J., and Wang J. (2019). miR-101 suppresses the development of MLL-rearranged acute myeloid leukemia. Haematologica 104(7):e296-e299. PMID:30792205.
Lynch, J., Salik, B., Connerty, P., Vick, B., Leung, H., Pijning, A., Jeremias, I., Spiekermann, K., Trahair, T., Liu, T., Haber, M., Norris, M., Woo, A., Hogg, P., Wang, J., and Wang, J. (2019). JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis. Leukemia 33(6):1400-1410. PMID:30622285.
2018
​Han, S., Tan, C., Ding, J., Wang, J., Ma’ayan, A., and Gouon-Evans, V. (2018). Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications. Stem Cell Research 30:163-170. PMID:29936335.
Kim, K.-Y., Tanaka, Y., Su, J., Cakir, B., Xiang, Y., Patterson, B., Ding, J., Jung, Y.-W., Kim, J.-H., Hysolli, E., Lee, H., Dajani, R., Kim, J., Zhong, M., Lee, J.-H., Skalnik, D., Lim, J.M., Sullivan, G., Wang, J., and Park, I.-H. (2018). Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a. Nature Communications 9(1):2583-2595. PMID:29968706.
Wang, J., Wu, X., Wei, C., Huang, X., Ma, Q., Huang, X., Faiola, F., Guallar, D., Fidalgo, M., Huang, T., Peng, D., Chen, L., Yu, H., Li, X., Sun, J., Liu, X., Cai, X., Chen, X., Wang, L., Ren, J., Wang, J.*, and Ding, J.* (2018). YY1 positively regulates transcription by targeting promoters and super-enhancers through the BAF complex in embryonic stem cells. Stem Cell Reports 10(4):1324-1339. PMID:29503092. (*Corresponding authors)
Guallar D., Bi, X., Pardavila, J.A., Huang, X., Saenz, C., Shi, X., Zhou, H., Faiola, F., Ding, J., Haruehanroengra, P., Yang, F., Li, D., Sanchez-Priego, C., Saunders, A., Pan, F., Valdes, V.J., Kelley, K., Blanco, M.G., Chen, L., Wang, H., Sheng, J., Xu, M., Fidalgo M., Shen, X., and Wang, J. (2018). RNA-dependent chromatin targeting of Tet2 for endogenous retrovirus control in pluripotent stem cells. Nature Genetics 50(3):443-451. PMID:29483655.
Zhang, Y., Xiang, Y., Yin, Q., Du, Z., Peng, X., Wang, Q., Fidalgo, M., Xia, W., Li, Y., Zhao, Z., Zhang, W., Ma, J., Xu, F., Wang, J., Li, L., and Xie, W. (2018). Dynamic epigenomic landscapes during early lineage specification in mouse embryos. Nature Genetics 50, 96-105. PMID: 29203909.
2017
Esteban, M.A. and Wang, J. (2017). Editorial overview: Cell reprogramming: Carpe diem. Curr. Opin. Genet. Dev. 46:iv-vi. PMID:28969756.
Huang, X.#, Balmer, S.#, Yang, F., Fidalgo, M., Li, D., Guallar, D., Hadjantonakis, A.-K.*, Wang, J.* (2017). Zfp281 is essential for epiblast maturation through transcriptional and epigenetic control of Nodal signaling in the mouse embryo. eLife 6. pii: e33333. doi: 10.7554/eLife.33333.  PMID:29168693. (*Corresponding authors)
Faiola, F., Yin, N., Fidalgo, M., Huang, X., Saunders, A., Ding, J., Guallar, D., Dang, B., and Wang, J. (2017). NAC1 regulates somatic cell reprogramming by conrolling Zeb1 and E-cadherin expression. Stem Cell Reports  9 (3): 913-926. PMID: 28781078.
Chen, Y., Pan, Y., Guo, Y., Zhao, W., Ho, W. T., Wang, J., Xu, M., Yang, F. C., and Zhao, Z. J. (2017). Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia. Stem Cell Investigation 4, 48-60. PMID:28607922. PMCID:5460107.
Huang, X., and Wang, J. (2017). Mitotic bookmarking: maintaining the stem cell identity during mitosis. Cell Stem Cell 20, 741-742. PMID: 28575687.
Huang, X., and Wang, J. (2017). ​A determined "hesitation" on H3K27me3 empowers stem cells to differentiate. Molecular Cell 66, 165–166. PMID: 28431228.
Saunders, A.#, Li, D.#, Faiola, F., Huang, X., Fidalgo, M., Guallar, D., Ding, J., Yang, F., Xu, Y., Zhou, H., and Wang, J. (2017). Context-dependent functions of NANOG phosphorylation in pluripotency and reprogramming. Stem Cell Reports 8(5):1115-1123. PMID: 28457890 
Pan, F., Wingo, T.S., Zhao, Z., Street, C., Yu, M., Qu, G., Ortega, J.R., Li, L., Faiola, F., Li, L., Nguyen, L., Wang, J., Makishima, H., Chen, S., Weeks, O., Liu, S., Maciejewski, J.P., Ni, H., Wang, J., He, C., Li, G.-M., Aifantis, I., Yang, F.-C., Jin, P., and Xu, M. (2017). Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells. Nature Communications 8:15102. doi: 10.1038/ncomms15102. PMID: 28440315.
Saunders, A., Huang, X., Fidalgo, M., Reimer, M., Faiola, F., Ding, J., Sanchez-Priego, C., Guallar, D., Saenz. C.,  Li, D., and Wang, J. (2017). The SIN3A/HDAC corepressor complex functionally cooperates with NANOG in promoting pluripotency. Cell Reports 18, 1713-1726.  PMID: 28199843.
2016
Fidalgo, M., Huang, X., Guallar, D., Sanchez-Priego, C., Valdes, V.J., Saunders, A., Ding, J., Wu, W.-S., Clavel, C., and Wang, J. (2016). Zfp281 coordinates opposing functions of Tet1 and Tet2 in pluripotent states. Cell Stem Cell 19(3):355-69. PMID: 27345836.
Yang, J., Guo, R., Wang, H., Ye, X., Zhou, Z., Dan, J., Wang, H., Gong, P., Deng, W., Yin, Y., Mao, S., Wang, L., Ding, J., Li, J., Keefe, D.L., Dawlaty, M.M., Wang, J., Xu, G., and Liu, L. (2016). Tet enzymes regulate telomere maintenance and chromosomal stability of mouse ESCs. Cell Reports 15, 1809-1821. PMID: 27184841.
Guallar D., and Wang J. (2016). Taking the RISC of exiting naive pluripotency. Genome Biology 17, 104-107.
​Luo, S., Lu, J.Y., Liu, L., Yin, Y., Chen, C., Han, X., Wu, B., Xu, R., Liu, W., Yan, P., Shao, W., Lu, Z., Li, H., Na, J., Tang, F., Wang, J., Zhang, Y.E., and Shen, X. (2016). Divergent lncRNAs regulate gene expression and lineage differentiation in pluripotent cells. Cell Stem Cell 18 (5), 637-652. PMID: 26996597.
2015
Aguilo, F., Zhang, F., Sancho, A., Fidalgo, M., Cecilia, S.D., Vashisht, A., Lee, D.-F., Chen, C.-H., Rengasamy, M., Andino, B., Jahouh, F., Roman, A., Krig, S.R., Wang, R., Zhang, W., Wohlschlegel, J.A., Wang, J., and Walsh, M.J. (2015). Coordination of m6A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming. Cell Stem Cell 17(6), 689-704. PMID: 26526723.​
Ding, J., Huang, X., Shao, N., Zhou, H., Lee, D.-F., Faiola, F., Fidalgo, M., Guallar, D., Saunders, A., Shliaha, P.V., Wang, H., Waghray, A., Papatsenko, D., Sánchez-Priego, C., Li, D., Yuan, Y., Lemischka, I.R., Shen, L., Kelley, K., Deng, H., Shen, X., and Wang, J. (2015). Tex10 coordinates epigenetic control of super-enhancer activity in pluripotency and reprogramming. Cell Stem Cell 16(6), 653-668. PMID: 25936917.
2014
Dietrich, P.A., Yang, C., Leung, H.H.L., Lynch, J.R., Gonzales, E., Liu, B., Haber, M., Norris, M.D., Wang, J., and Wang, J.Y. (2014). GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis. Blood 124(22), 3284-94. PMID: 25293777. 
Gingold, J.A.#, Fidalgo, M.#, Guallar, D., Lau, Z., Sun, Z., Zhou, H., Faiola, F., Huang, X., Lee, D.-F., Waghray, A., Schaniel, C., Felsenfeld, D.P., Lemischka, I.R.*, and Wang, J.* (2014). A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Molecular Cell 56(1), 140-152. (Cover Image). PMID: 25240402. (*Corresponding authors)
Huang, X. and Wang, J. (2014). The extended pluripotency protein interactome and its links to reprogramming. Current Opinion in Genetics & Development 28, 16–24. PMID: 25173149
Guallar, D. and Wang, J. (2014). RNA-binding proteins in pluripotency, differentiation and reprogramming. Frontiers in Biology 9(5), 389-409. PMID: 25554730.
Saunders, A. and Wang J. (2014). Export and Expression: mRNAs Deliver New Messages for Controlling Pluripotency. Cell Stem Cell 14(5), 549-550. PMID: 24792108.
Faiola, F., Saunders, A., Dang, B., and Wang, J. (2014). An improved in vivo biotinylation strategy combined with FLAG and antibody based approaches for affinity purification of protein complexes in mouse embryonic stem cells. Methods in Molecular Biology 1177 (Protein Affinity Tags-Methods and Protocols), Chapter 11, 135-149.
2013
Saunders, A. and Wang J. (2013). Pursuing self-renewal and pluripotency with the stem cell factor Nanog. Stem Cells 31(7), 1227-1236. PMID: 23653415.
Yap, K.L., Sysa-Shah, P. Bolon, B., Wu, R.-C., Gao, M., Herlinger, A.L., Wang, F., Faiola, F., Huso, D., Gabrielson, K., Wang, T.-L., Wang, J.*, Shih, I.M.*,  (2013). Loss of NAC1 expression is associated with defective bony patterning in the murine vertebral axis. PLOS One 8(7):e69099. PMID: 23922682. (*Corresponding authors)
Costa, Y.#, Ding, J.#, Theunissen, T.W.#, Faiola, F.#, Hore, T. A., Shliaha, P.V., Fidalgo, M., Saunders, A., Lawrence, M., Dietmann, S., Das, S., Levasseur, D.N., Li, Z., Xu, M., Reik, W., Silva, J.C.R.*, and Wang, J.* (2013). NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature 495, 370-374. PMID: 23395962. (*Corresponding authors)
2012
MacArthur, B.D., Sevilla, A., Lenz, M., Muller, F.-J., Schuldt, B.M., Schuppert, A.A., Ridden, S.J., Stumpf, P.S., Fidalgo, M., Ma'ayan, A., Wang, J., and Lemischka, I.R. (2012). Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nat. Cell Biol 14(11), 1139-1147. PMID: 23103910.
Fidalgo, M., Faiola, F., Pereira, C.-F., Ding, J., Saunders, A., Gingold, J., Schaniel, C., Lemischka, I.R., Silva, J., and Wang, J. (2012). Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc. Natl. Acad. Sci. USA  109(40), 16202-16207. PMID: 22988117.
Ando K., Kernan, J.L., Liu, P.H., Sandra, T., Logette, E., Tschopp, J., Look, A. T., Wang, J., Bouchier-Hayes, L., and Sidi, S. (2012). PIDD death-domain phosphorylation by ATM determines prodeath versus prosurvival PIDDosome. Molecular Cell 47, 681-693. PMID: 22854598.  
Yap, K.L., Fraley, S.I., Thiaville, M.M., Jinawath, N., Nakayama, K., Wang, J., Wang, T.-L., Wirtz, D., Shih, I.M. (2012). NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells. Cancer Res. 72, 4085–4096. PMID: 22761335.
Wang, J. (2012). Deciphering protein complexes and protein interaction networks for stem cell pluripotency. New Frontiers of Network Analysis in Systems Biology (Edited by A. Ma'ayan and B. MacArthur), Chapter 6, 97-118. 
Ding, J., Xu, H., Faiola, F., Ma’ayan, A., and Wang, J. (2012). Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Research 22, 155-167. PMID: 22083510. PMCID:PMC3252465
2011
Fidalgo, M., Shekar, P.C., Ang, Y.S., Fujiwara, Y., Orkin, S.H., and Wang, J. (2011). Zfp281 functions  as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem cells 29 (11), 1705-1716. PMID: 21915945.
Ang, Y.S., Tsai, S.Y., Lee, D.F., Monk, J., Su, J., Ratnakumar, K., Ding, J., Ge, Y., Darr, H., Chang, B., Wang, J., Rendl, M., Bernstein, E., Schaniel, C., Lemischka, I.R. (2011). Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell 145, 183-197. PMID: 21477851.
2009-2010
Wang, J. (2010). Efficient gene knockdowns in mouse embryonic stem cells using microRNA-based shRNAs. Methods in Molecular Biology 650, 241-256. PMID: 20686956.
Wang, J.*, Cantor, A.B., and Orkin, S.H. (2009). Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Current Protocols in Stem Cell Biology 1B.5.1-1B.5.17 (*Corresponding author). PMID: 19306258. PMCID: PMC2782545.
Kim, J., Cantor, A.B., Orkin, S.H., and Wang, J. (2009). Use of in vivo biotinylation both protein-protein and protein-DNA interaction networks in mouse embryonic stem cells. Nature Protocols 4, 506-517. PMID: 19325547.
stem cell